NTP CHEMICAL REPOSITORY
(RADIAN CORPORATION, AUGUST 29, 1991)
ETHOXYQUIN
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 002195
*CAS NUMBER: 91-53-2
*BASE CHEMICAL NAME: ETHOXYQUIN
*PRIMARY NAME: ETHOXYQUIN
*CHEMICAL FORMULA: C14H19NO
*STRUCTURAL FORMULA: Not printable
*WLN: T66 BM CHJ C1 C1 E1 HO2
*SYNONYMS:
6-ETHOXY-1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
6-ETHOXY-2,2,4-TRIMETHYL-1,2-DIHYDROQUINOLINE
1,2-DIHYDRO-6-ETHOXY-2,2,4-TRIMETHYLQUINOLINE
1,2-DIHYDRO-2,2,4-TRIMETHYL-6-ETHOXYQUINOLINE
2,2,4-TRIMETHYL-6-ETHOXY-1,2-DIHYDROQUINOLINE
EMQ
EQ
ETHOXYQUINE
SANTOFLEX A
SANTOFLEX AW
STOP-SCALD
NIX-SCALD
NIFLEX
SANTOQUINE
SANTOQUIN
ANTIOXIDANT EC
PERMANAX 103
AMEA 100
DAWE'S NUTRIGARD
QUINOL ED
NOCRAC AW
NIFLEX D
ANTOX
ARIES ANTOX
ANTAGE AW
USAF B-24
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION: LITERATURE: Clear, light yellow to dark brown, viscous
liquid
REPOSITORY: Dark brown liquid
*MOLECULAR WEIGHT: 217.34
*SPECIFIC GRAVITY: 1.029-1.031 @ 25/25 C [031,058,062,169]
*DENSITY: 1.030 g/mL @ 25 C [043]
*MP (DEG C): <0 C [043,107]
*BP (DEG C): 123-125 C @ 2 mm Hg [031,047,058,107]
*SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Oils: Soluble [295]
Fats: Soluble [295]
Organic solvents: Soluble [295]
*VOLATILITY:
Vapor pressure: 0.0000182 mm Hg @ 0 C; 0.000256 mm Hg @ 25 C [058]
Vapor density : 7.48 [043]
*FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 107 C (225 F) [058]. It is
combustible. Fires involving this material can be controlled with a
dry chemical, carbon dioxide or Halon extinguisher. A water spray may
also be used [058].
*UEL: Not available LEL: Not available
*REACTIVITY:
This chemical may react with oxidizing materials [043,107]. It also
reacts with strong acids [058].
*STABILITY:
Hazardous polymerization of this chemical may occur at temperatures above
160 C [058]. It tends to polymerize and darken in color on exposure to light
and air [295]. UV spectrophotometric stability screening indicates that
solutions of this chemical in acetone are stable for at least 24 hours (RAD).
*OTHER PHYSICAL DATA:
Refractive index: 1.569-1.672 @ 25 C [031,169]
Discolors and stains badly [062,107]
Mercaptan-like odor [058]
Flash point (open cup): 140-143 C (285-290 F) [058]
-TOXICITY
========
*NIOSH REGISTRY NUMBER: VB8225000
*TOXICITY:
typ. dose mode specie amount units other
LD50 ipr mus 200 mg/kg
LD50 orl mus 1730 mg/kg
LD50 orl rat 800 mg/kg
LD50 ivn mus 178 mg/kg
*AQTX/TLM96: Not available
*SAX TOXICITY EVALUATION:
THR: Poison by intraperitoneal route. Moderately toxic by ingestion.
Mutagenic data.
*CARCINOGENICITY: Not available
*MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mma-sat 200 ug/plate |
*TERATOGENICITY: Not available
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
*OTHER TOXICITY DATA:
Status: EPA Genetox Program 1988, Negative: Histidine reversion-Ames test
EPA Genetox Program 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Chemical Inventory, 1986
EPA TSCA Test Submission (TSCATS) Data Base, June 1988
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Not restricted
*UN/ID NUMBER:
*HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
*LABELS REQUIRED:
*PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
*SPECIAL PROVISIONS:
*USES:
This compound is used as a food additive. It is also used as an
antidegradation agent for rubber, insecticide, antioxidant, flex-cracking
inhibitor, post-harvest dip to prevent scald on apples and pears, fungicide
and plant growth regulator.
*COMMENTS:
This compound is permitted in the food and drinking water of animals.
It is also permitted in food for human consumption [043].
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
This compound may cause irritation of the skin and eyes [058]. When
heated to decomposition it emits toxic fumes of carbon monoxide, carbon
dioxide and nitrogen oxides [043,058]. It may cause lacrimation [107].
*MINIMUM PROTECTIVE CLOTHING: Not available
*RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Butyl rubber North B-174 0.63 mm 240 min
*RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
*OTHER: Not available
*STORAGE PRECAUTIONS:
You should protect this chemical from exposure to light. Keep
the container tightly closed under an inert atmosphere, and store
under refrigerated temperatures.
*SPILLS AND LEAKAGE:
If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then,
use absorbent paper to pick up all liquid spill material. Your contaminated
clothing and absorbent paper should be sealed in a vapor-tight plastic bag for
eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol
followed by washing with a soap and water solution. Do not reenter the
contaminated area until the Safety Officer (or other responsible person) has
verified that the area has been properly cleaned.
*DISPOSAL AND WASTE TREATMENT: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this compound include skin irritation [058,107,
151]. It can cause eye irritation [058]. It can also cause skin sensitiza-
tion (allergic reactions), lacrimation, depression, reproductive effects,
liver effects, kidney effects and thyroid effects [107]. Dermatitis may also
occur [107,295].
Parenteral administration of this compound to laboratory animals produces
convulsions, coma and prompt death [151].
-SOURCES
=======
*SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. On-line Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. VB8225000.
March 7, 1989.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 545, #3703.
[043] Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial
Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989.
Vol. III, p. 3000, #SAV000.
[047] Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on
Organic Compounds. CRC Press, Inc. Boca Raton, FL.
1985. Vol. I, p. 612, #E00436.
[058] Information Handling Services. Material Safety Data Sheets
Service. Microfiche Ed. Bimonthly Updates. February/March
1989. #1805-015, C-03; #5972-003, F-10.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 476.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. March 15, 1989.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. p. II-406, #1615.
[165] Wiswesser, W.J., Ed. Pesticide Index. Entomological Society
of America. College Park, MD. 1976. p. 107.
[169] Hartley, Douglas B.Sc., Ph.D., M.I.Inf.Sc. and Hamish Kidd B.Sc., Eds.
The Agrochemicals Handbook. 2nd Ed. The Royal Society of Chemistry.
Nottingham, England. 1987. Listed.
[186] Sittig, Marshall, Ed. Pesticide Manufacturing and Toxic Materials
Control Encyclopedia. Noyes Data Corporation. Park Ridge, NJ.
1980. pp. 388-389.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. p. 1286.
[401] Nutt, A. R. Toxic Hazards of Rubber Chemicals. Elsevier
Applied Science Publishers. New York. 1984. p. 101.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Not listed.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990.
Not listed.
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