NTP CHEMICAL REPOSITORY
(RADIAN CORPORATION, AUGUST 29, 1991)
BUTYLATED HYDROXYANISOLE
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 001430
*CAS NUMBER: 25013-16-5
*BASE CHEMICAL NAME: BUTYLATEDHYDROXYANISOLE
*PRIMARY NAME: BUTYLATED HYDROXYANISOLE
*CHEMICAL FORMULA: C11H16O2
*STRUCTURAL FORMULA: CH3OC6H2(OH)C(CH3)3
*WLN: Not available
*SYNONYMS:
(1,1-DIMETHYLETHYL)-4-METHOXYPHENOL
BHA
BUTYLHYDROXYANISOLE
TERT-BUTYLHYDROXYANISOLE
TERT-BUTYL-4-HYDROXYANISOLE
TERT-BUTYL-P-HYDROXYANISOLE
ANTIOXYNE B
ANTRANCINE 12
2(3)-TERT-BUTYL-4-HYDROXYANISOLE
TERT-BUTYL-4-METHOXYPHENOL
2-TERT-BUTYL-4-METHOXYPHENOL
EEC NO. E320
EMBANOX
NIPANTIOX 1-F
PROTEX
PREMERGE PLUS
SUSTANE
SUSTANE 1-F
SUSTAN 1-F
VERTAC
TENOX BHA
BOA (ANTIOXIDANT)
BOA
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION: LITERATURE: White or slightly yellow waxy solid
REPOSITORY: Beige solid
*MOLECULAR WEIGHT: 180.27
*SPECIFIC GRAVITY: Not available
*DENSITY: Not available
*MP (DEG C): 48-55 C [031,395]
*BP (DEG C): 264-270 C @ 733 mm Hg [031,395]
*SOLUBILITIES:
WATER : <1 mg/mL @ 18.5 C (RAD)
DMSO : >=100 mg/mL @ 18.5 C (RAD)
95% ETHANOL : >=100 mg/mL @ 18.5 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 18.5 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Petroleum ether: Soluble [031,395]
Propylene glycol: 1 part/2 parts @ 20 C [295,455]
Fats and oils: Soluble [031,395]
Alcohol: 1 part/4 parts @ 20 C [295,455]
Liquid paraffin: 1 part/100 parts @ 20 C [295,455]
Chloroform: 1 part/2 parts [295]
Arachis oil: 1 part/3 parts @ 20 C [295,455]
Lard: 1 part/4 parts @ 20 C [295,455]
Ether: 1 part/1.2 parts [295]
Solutions of alkali hydroxides: Soluble [295,455]
50% Ethanol: Soluble [395]
*VOLATILITY:
Vapor pressure: Not available
Vapor density : Not available
*FLAMMABILITY(FLASH POINT):
The flash point for this chemical is 156 C (313 F) [395]. It is combustible.
Fires involving this compound can be controlled with a dry chemical, carbon
dioxide or Halon extinguisher.
*UEL: Not available LEL: Not available
*REACTIVITY:
This compound exhibits antioxidant properties and synergism with acids,
BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic
acid [031]. It exhibits antioxidant properties as a scavenger of free radi-
cals [395]. It is incompatible with oxidizing agents and ferric salts [295].
*STABILITY:
This chemical degrades following prolonged exposure to sunlight [395]. Solu-
tions of this chemical in water, DMSO, 95% ethanol or acetone should be stable
for 24 hours under normal lab conditions (RAD).
*OTHER PHYSICAL DATA:
Aromatic odor
Slightly bitter burning taste
Dissolves readily in molten fats
Not naturally soluble in water but can be made so by special treatment
-TOXICITY
========
*NIOSH REGISTRY NUMBER: SL1945000
*TOXICITY:
typ. dose mode specie amount unit other
LD50 orl rat 2 gm/kg
LD50 orl mus 1100 mg/kg
LD50 orl rbt 2100 mg/kg
LD50 ipr rat 881 mg/kg
*AQTX/TLM96: Not available
*SAX TOXICITY EVALUATION:
THR: MODERATE via oral route. Used as an antioxidant in foods. MUTATION
data. An experimental equivocal tumorigenic agent.
*CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-rat 728 gm/kg/2Y-C
TDLo: orl-mus 874 gm/kg/1Y-C
TDLo: orl-ham 437 gm/kg/1Y-C
TD : orl-ham 202 gm/kg/24W-C
TD : orl-rat 874 gm/kg/2Y-C
TD : orl-rat 182 gm/kg/2Y-C
TD : orl-rat 218 gm/kg/2Y-C
TD : orl-rat 269 gm/kg/32W-C
TD : orl-rat 876 gm/kg/2Y-C
TD : orl-rat 4200 mg/kg/10W-C
TD : orl-rat 728 gm/kg/2Y-C
TD : orl-rat 874 gm/kg/1Y-C
TD : orl-rat 202 gm/kg/24W-C
Review: IARC Cancer Review: Animal Sufficient Evidence
IARC possible human carcinogen (Group 2B) [610]
*MUTATION DATA:
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-omi 12500 ug/L | sce-ham:fbr 100 umol/L
dns-rat-orl 176 gm/kg/21W-C |
*TERATOGENICITY:
Reproductive Effects Data:
TDLo: orl-rat 30 gm/kg (2W male/2W pre-2W post)
TDLo: orl-rat 36 gm/kg (2W male/2W pre-3W post)
TDLo: orl-mus 12600 mg/kg (1-21D preg)
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): None
Flammability (F): None
Reactivity (R): None
*OTHER TOXICITY DATA:
Review: Toxicology Review
Status: EPA TSCA Chemical Inventory, 1986
EPA Genetox Program 1986, Positive/limited: Carcinogenicity-mouse/rat
EPA Genetox Program 1986, Negative: Histidine reversion-Ames test
EPA Genetox Program 1986, Negative: D melanogaster Sex-linked lethal
EPA Genetox Program 1986, Inconclusive: D melanogaster-whole sex
chrom. loss
EPA Genetox Program 1986, Inconclusive: In vitro SCE-nonhuman
Meets criteria for proposed OSHA Medical Records Rule
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Not restricted
*UN/ID NUMBER:
*HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
*LABELS REQUIRED:
*PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
*SPECIAL PROVISIONS:
*USES:
Antioxidant in fat-containing foods and in edible fats and oils; prevents
food from becoming rancid and developing objectionable odors; preservative
and antioxidant in cosmetic formulations.
*COMMENTS:
Commercially available food-grade BHA is generally a mixture containing
>85% 3-tert-butyl-4-hydroxyanisole and <15% of the 2-tert-butyl isomer
[395]. The use of this chemical in foods is restricted [062].
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
This compound is toxic by ingestion [062]. There is sufficient evidence that
it is carcinogenic in animals [015,395]. When heated to decomposition this
compound emits acrid smoke and irritating fumes [042].
*MINIMUM PROTECTIVE CLOTHING:
If Tyvek-type disposable protective clothing is not worn during
handling of this chemical, wear disposable Tyvek-type sleeves taped to
your gloves.
*RECOMMENDED GLOVE MATERIALS:
Recommended Glove Type For Use With Neat (Undiluted) Chemical:
Recommendations based on permeation test results are made for handling
the neat (undiluted) chemical. If this chemical makes direct contact with
your glove, or if a tear, puncture or hole develops, replace them at once.
Suggested Glove Type(s) (RAD): No information available
*RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with a combination filter cartridge,
i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid
gas, SO2 and a high efficiency particulate filter).
*OTHER:
Since this chemical is a known or suspected carcinogen you should contact
a physician for advice regarding the possible long term health effects and
potential recommendation for medical monitoring. Recommendations from the
physician will depend upon the specific compound, its chemical, physical and
toxicity properties, the exposure level, length of exposure, and the route
of exposure.
*STORAGE PRECAUTIONS:
You should protect this material from exposure to light. Keep it away
from oxidizing materials and store it at ambient temperatures.
*SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
*DISPOSAL AND WASTE TREATMENT: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
IMMEDIATELY call a hospital or poison control center even if no symptoms
(such as redness or irritation) develop.
IMMEDIATELY transport the victim to a hospital for treatment after
washing the affected areas.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a
hospital even if no symptoms (such as wheezing, coughing, shortness of breath,
or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this compound may include allergic contact derma-
titis, exacerbation of vasomotor rhinitis, conjunctival irritation and red-
ness, asthma, facial flushing, marked diaphoresis, headaches, dull retro-
sternal pain and somnolence [430]. It may also cause hypersensitivity reac-
tions after skin contact [295].
Symptoms of exposure in laboratory animals include hemorrhages and liver
lesions [151]. It may also cause hyperplasia and hyperkeratosis in the
stomach mucosa [395].
-SOURCES
=======
*SOURCES:
[015] Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects
of Chemical Substances. Microfiche Ed. National Institute for
Occupational Safety and Health. Cincinnati, OH. Quarterly
Updates. SL1945000.
[031] Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.
Rahway, NJ. 1983. p. 215, #1520.
[042] Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.
Van Nostrand Reinhold. New York. 1984. p. 570.
[052] Midwest Research Institute. MRI Report for Butylated Hydroxy Anisole.
Kansas City, MO. July 18, 1984.
[062] Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical
Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987.
p. 183.
[082] U.S. Environmental Protection Agency, Office of Toxic Substances.
Toxic Substances Control Act Chemical Substance Inventory: 1985
Edition. 5 Vols. U.S. Environmental Protection Agency.
Washington, D.C. January 1986. Listed.
[107] Occupational Health Services, Inc. Hazardline. Occupational
Health Services, Inc. New York. Listed.
[110] Oak Ridge National Laboratory. Environmental Mutagen Information
Center (EMIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[120] Oak Ridge National Laboratory. Environmental Teratogen Information
Center (ETIC), Bibliographic Data Base. Oak Ridge National
Laboratory. Oak Ridge, TN. Listed.
[151] Gosselin, R.E., H.C. Hodge, and R.P. Smith. Clinical Toxicology
of Commercial Products. 5th Ed. Williams and Wilkins, Co.
Baltimore. 1984. pp. II-405 to II-406, #1614.
[195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds. CFTA Cosmetic
Ingredient Dictionary. 3rd Ed. The Cosmetic, Toiletry and
Fragrance Assn. Inc. Washington. 1982. pp. 27-28.
[295] Reynolds, James E.F., Ed. Martindale The Extra Pharmacopoeia. 28th Ed.
The Pharmaceutical Press. London. 1982. pp. 1284-1285.
[365] Connors, Kenneth A., Gordon L. Amidon and Valentino J. Stella. Chemical
Stability of Pharmaceuticals: A Handbook for Pharmacists. 2nd Ed.
John Wiley & Sons. New York. 1986. p. 103.
[395] International Agency for Research on Cancer, World Health
Organization. IARC Monographs on the Evaluation of
Carcinogenic Risk of Chemicals to Man. International
Agency for Research on Cancer. Geneva. Vol. 40, pp. 123-159.
[430] Clayton, G.D. and F.E. Clayton, Eds. Patty's Industrial Hygiene
and Toxicology. Vol. 2. Third Revised Edition. John Wiley
and Sons. New York. 1981. Vol. IIA, pp. 2536-2539.
[455] The Pharmaceutical Society of Great Britain. The Pharmaceutical Codex.
11th Edition. The Pharmaceutical Press. London. 1979. p. 117.
[610] Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to
Industrial Chemicals Covered Under Major Federal Regulatory and
Advisory Programs. Roytech Publications, Inc. Burlingame, CA.
1990. Section 3, p. 148.
[620] United States National Toxicology Program. Chemical Status Report.
NTP Chemtrack System. Research Triangle Park, NC. October 3, 1990.
Not listed.
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