NTP CHEMICAL REPOSITORY
(RADIAN CORPORATION, AUGUST 29, 1991)
PROPYL GALLATE
-IDENTIFIERS
===========
*CATALOG ID NUMBER: 000661
*CAS NUMBER: 121-79-9
*BASE CHEMICAL NAME: PROPYLGALLATE
*PRIMARY NAME: PROPYL GALLATE
*CHEMICAL FORMULA: C10H12O5
*STRUCTURAL FORMULA: (HO)3C6H2COOCH2CH2CH3
*WLN: QR BQ CQ EVO3
*SYNONYMS:
GALLIC ACID, PROPYL ESTER
3,4,5-TRIHYDROXYBENZOIC ACID, PROPYL ESTER
N-PROPYL GALLATE
PROPYL 3,4,5-TRIHYDROXYBENZOATE
3,4,5-TRIHYDROXYBENZENE-1-PROPYLCARBOXYLATE
N-PROPYL ESTER OF 3,4,5-TRIHYDROXYBENZOIC ACID
3,4,5-TRIHYDROXYBENZOIC ACID, N-PROPYL ESTER
N-PROPYL 3,4,5-TRIHYDROXYBENZOATE
NIPAGALLIN P
PROGALLIN P
PG
TENOX PG
NIPA 49
BENZOIC ACID, 3,4,5-TRIHYDROXY-, PROPYL ESTER
-PHYSICAL CHEMICAL DATA
======================
*PHYSICAL DESCRIPTION:
LITERATURE: White to creamy-white crystalline powder
REPOSITORY: Fine white powder
*MOLECULAR WEIGHT: 212.20
*SPECIFIC GRAVITY: 1.21 [058]
*DENSITY: Not available
*MP (DEG C): 150 C [029,033,062,205]
*BP (DEG C): Decomposes [058]
*SOLUBILITIES:
WATER : <1 mg/mL @ 20 C (RAD)
DMSO : >=100 mg/mL @ 20 C (RAD)
95% ETHANOL : >=100 mg/mL @ 20 C (RAD)
METHANOL : Not available
ACETONE : >=100 mg/mL @ 20 C (RAD)
TOLUENE : Not available
OTHER SOLVENTS:
Ether: 83 g/100 g @ 25 C [033]
Propylene glycol: 1 in 3 [295]
Lard: 1.14 g/100 g @ 45 C [033]
Oils: Soluble [062]
Alcohol: 103 g/100 g @ 25 C [033]
Cottonseed oil: 1.23 g/100 g @ 30 C [033]
Arachis oil: Soluble in 2000 parts [295,455]
*VOLATILITY:
Vapor pressure: Not available
Vapor density : 7.3 [058]
*FLAMMABILITY(FLASH POINT):
This chemical has a flash point of 187 C (368 F) [058]. It is combus-
tible. Fires involving this material can be controlled with a dry chemical,
carbon dioxide or Halon extinguisher.
*UEL: Not available LEL: Not available
*REACTIVITY:
This chemical can react with oxidizers [043,058,269]. It is incompatible
with strong acids, strong bases and strong reducing agents [269]. It darkens
in the presence of iron and iron salts [033,430]. It is synergic with acids,
BHA and BHT [033]. Contact with metals should be avoided [295,455].
*STABILITY:
This chemical is stable under normal laboratory conditions [052,058].
UV spectrophotometric stability screening indicates that solutions of this
chemical in 95% ethanol are stable for at least 24 hours (RAD).
*OTHER PHYSICAL DATA:
Nonvolatile [058]
Odorless or with a faint odor [295]
Slightly bitter taste [295,455]
UV max (in 95% ethanol): 276 nm, 218 nm (epsilon = 10510, 26500) [052]
UV max (in methyl alcohol): 275 nm (E = 490) [455]
Melting point also reported as 130 C [016,047]
-TOXICITY
========
*NIOSH REGISTRY NUMBER: LW8400000
*TOXICITY:
typ. dose mode specie amount units other
LD50 orl rat 2100 mg/kg
LD50 ipr rat 380 mg/kg
LD50 orl mus 1700 mg/kg
LD50 orl cat 400 mg/kg
LD50 unr rat 2500 mg/kg
LD50 orl rbt 2750 mg/kg
LD50 orl ham 2480 mg/kg
*AQTX/TLM96: Not available
*SAX TOXICITY EVALUATION:
THR: Poison by ingestion and intraperitoneal routes. An experimental
tumorigen. Experimental teratogenic and reproductive effects.
Mutagenic data.
*CARCINOGENICITY:
Tumorigenic Data:
TDLo: orl-mus 168 gm/kg/2Y-C
Status: NTP Carcinogenesis Bioassay (Feed); Equivocal: Male Rat and Male
Mouse [620]
NTP Carcinogenesis Bioassay (Feed); Negative: Female Rat and Female
Mouse [620]
*MUTATION DATA: See RTECS printout for most current data
test lowest dose | test lowest dose
----------- ----------------- | ----------- -----------------
mmo-sat 200 ug/plate | cyt-ham:lng 10 mg/L
mma-sat 200 ug/plate | cyt-ham:fbr 40 mg/L
msc-mus:lym 12500 ug/L | cyt-ham:ovr 5 mg/L
sce-ham:ovr 5 mg/L |
*TERATOGENICITY: See RTECS printout for most current data
Reproductive Effects Data:
TDLo: orl-rat 45 gm/kg (1-22D preg)
TDLo: orl-rat 19 gm/kg (1-22D preg)
TDLo: orl-rat 2500 mg/kg (1-22D preg)
*STANDARDS, REGULATIONS & RECOMMENDATIONS:
OSHA: None
ACGIH: None
NIOSH Criteria Document: None
NFPA Hazard Rating: Health (H): 1
Flammability (F): 1
Reactivity (R): 0
H1: Materials only slightly hazardous to health (see NFPA for details).
F1: Materials that must be preheated before ignition can occur (see NFPA
for details).
R0: Materials which are normally stable even under fire exposure conditions
and which are not reactive with water (see NFPA for details).
*OTHER TOXICITY DATA:
Review: Toxicology Review
Status: EPA TSCA Chemical Inventory, 1989
-OTHER DATA (Regulatory)
=======================
*PROPER SHIPPING NAME (IATA): Not restricted
*UN/ID NUMBER:
*HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP:
*LABELS REQUIRED:
*PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY:
CARGO : PKG. INSTR.: MAXIMUM QUANTITY:
*SPECIAL PROVISIONS:
*USES:
This compound is used as a food preservative and antioxidant for foods,
fats, oils, flavorings, ethers, emulsions, waxes and transformer oils. It is
used as a packaging material. It is also used to inhibit autooxidation of
paraldehyde and similar substances which develop peroxides in the presence of
oxygen.
*COMMENTS: Not available
-HANDLING PROCEDURES
===================
*ACUTE/CHRONIC HAZARDS:
This compound may be harmful by inhalation or ingestion. It is an
irritant of the skin, eyes, mucous membranes and upper respiratory tract
[269]. When heated to decomposition it emits acrid smoke, irritating fumes
and toxic fumes of carbon monoxide and carbon dioxide [043,058,269].
*MINIMUM PROTECTIVE CLOTHING: Not available
*RECOMMENDED GLOVE MATERIALS:
GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
This chemical has not been tested for permeation by Radian Corporation;
however, the GlovES+ expert system was used to extrapolate permeation test
information from compounds in the same chemical class. The GlovES+ system uses
permeation data from literature sources; therefore, extra safety margins should
be used with the estimated protection time(s). If this chemical makes direct
contact with your glove, or if a tear, puncture or hole develops, replace them
at once.
The GlovES+ expert system is a tool that can help people better manage
protection from chemicals, however this tool cannot replace sound judgment nor
make technical decisions. Our GlovES+ expert system is designed to offer
initial advice and assistance in glove selection while the final glove
selection should be made by knowledgeable individuals based on the specific
circumstances involved.
Glove Type Model Number Thickness Estimated Protection Time
Nitrile Edmont 37-165 0.60 mm 360 min
Unknown North Silvershield 0.10 mm 480 min
Neoprene Pioneer N-44 0.74 mm 480 min
Viton North F-091 0.29 mm 480 min
*RECOMMENDED RESPIRATOR:
Where the neat test chemical is weighed and diluted, wear a NIOSH-
approved half face respirator equipped with an organic vapor/acid gas
cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
dust/mist filter.
*OTHER: Not available
*STORAGE PRECAUTIONS:
You should store this chemical under ambient temperatures,
and keep it away from oxidizing materials.
*SPILLS AND LEAKAGE:
Should a spill occur while you are handling this chemical, FIRST REMOVE
ALL SOURCES OF IGNITION, then you should dampen the solid spill material with
60-70% ethanol and transfer the dampened material to a suitable container. Use
absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated,
in a vapor-tight plastic bag for eventual disposal. Solvent wash all contamin-
ated surfaces with 60-70% ethanol followed by washing with a soap and water
solution. Do not reenter the contaminated area until the Safety Officer (or
other responsible person) has verified that the area has been properly cleaned.
*DISPOSAL AND WASTE TREATMENT: Not available
-EMERGENCY PROCEDURES
====================
*SKIN CONTACT:
IMMEDIATELY flood affected skin with water while removing and isolating
all contaminated clothing. Gently wash all affected skin areas thoroughly
with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a
physician and be prepared to transport the victim to a hospital for treatment.
*INHALATION:
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in
the mouth, throat, or chest) develop, call a physician and be prepared to
transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown
atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)
should be used; if not available, use a level of protection greater than or
equal to that advised under Respirator Recommendation.
*EYE CONTACT:
First check the victim for contact lenses and remove if present. Flush
victim's eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without
specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if
no symptoms (such as redness or irritation) develop.
*INGESTION:
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing,
give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
hospital or poison control center. Be prepared to transport the victim to a
hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth,
ensure that the victim's airway is open and lay the victim on his/her side with
the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport
the victim to a hospital.
*SYMPTOMS:
Symptoms of exposure to this compound may include irritation of the
skin, eyes, mucous membranes and upper respiratory tract [269]. Other symp-
toms include gasping respirations and convulsions [151,430]. Brief skin
contact may dry the skin. Prolonged or repeated contact can cause dermatitis
and sensitization of the skin. Aspiration into the lungs may cause chemical
pneumonia [058].
-SOURCES
=======
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